1. there's no (other) way
2. cannot be helped; unavoidable; inevitable; (there's) nothing one can do; having no choice
3. it's no use (doing); pointless; useless; no good; insufficient; not enough
oft. as 〜ても仕方ない
4. hopeless (person); annoying; troublesome; awful
5. cannot stand it; unbearable; cannot help (doing, feeling); dying (to do)
as 〜て仕方ない or 〜で仕方ない